What effect can nonsteroidal anti-inflammatory drugs (NSAIDs) have on individuals at risk for cardiovascular issues?

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risks, particularly in individuals who already have underlying cardiovascular issues or those predisposed to them. The mechanism behind this association involves several factors. NSAIDs may lead to fluid retention, increased blood pressure, and alterations in the function of platelets, thereby elevating the risk of adverse cardiovascular events such as myocardial infarctions and strokes.

Studies have shown that the use of certain types of NSAIDs, especially at high doses or for extended periods, can contribute to cardiovascular events. The cumulative impact of these factors underscores the importance of cautious use of NSAIDs in patients with existing cardiovascular disease or risk factors, prompting healthcare providers to recommend alternatives or monitor the patient closely if NSAIDs are necessary.

The other options do not accurately capture the primary risk associated with NSAIDs in this context. For instance, while NSAIDs can contribute to kidney issues, leading to altered renal function, heightened renal function is not an effect of NSAIDs. Furthermore, their impact on anticoagulants may vary, but they do not significantly decrease their effectiveness in a way that represents a primary concern in patients at risk for cardiovascular issues. Lastly, the risk of infection is not directly linked to NSAID use in individuals