Which of the following is NOT a symptom of end-stage liver disease?

Malaise is often a subjective sensation that can accompany a variety of health issues, including end-stage liver disease, but it is not considered a key or defining symptom of the condition itself. In contrast, coagulopathy—characterized by an impaired ability to form blood clots due to the liver's role in producing clotting factors—is a well-documented symptom of end-stage liver disease. Malnutrition is also a significant concern in these patients due to the liver's crucial role in metabolism and nutrient storage. Furthermore, hepatic encephalopathy is a neurological manifestation arising from the liver's inability to detoxify the blood, leading to a buildup of toxins such as ammonia.

While malaise can certainly be a common complaint among individuals with any chronic illness, it lacks the specific association to liver dysfunction that the other symptoms demonstrate, making it the least representative of the typical clinical picture in end-stage liver disease.